EPA/DHA–Glucosamine

* Fish oil moderates prostaglandin and leukotriene production, supporting healthy connective tissue. It also plays a role in moderating neutrophil activity, supporting joint comfort. A double blind, placebo–controlled, prospective study involving 66 subjects revealed that fish oil modulates immune mediator activity as well as provides support for joint flexibility. Glucosamine is a naturally occurring compound necessary for the synthesis of proteoglycans, the protein molecules responsible for giving cartilage its strength and resilience. Sulfate, another component of proteoglycans, works synergistically with glucosamine to enhance cartilage metabolism. Boswellia serrata is an Ayurvedic herb that has a long history of use for connective tissue and joint support. Boswellic acids, the active terpenoid constituents of boswellia, may maintain healthy 5–lipoxygenase enzyme activity and healthy leukotriene metabolism to promote joint comfort. Curcumin also promotes joint comfort by supporting healthy histamine production, eicosanoid metabolism and neutrophil response.